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Stereoselective Synthesis for Potential Isomers of Ticagrelor Key Starting Material
Author(s) -
Mahender Madaraboina,
Yakambaram B.,
Pandey Jaya,
Chandrashekar E. R. R.,
Reddy L. Amarnath,
Jayashree A.,
Bandichhor Rakeshwar
Publication year - 2019
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.3677
Subject(s) - chemistry , stereoselectivity , tartrate , amine gas treating , ticagrelor , combinatorial chemistry , key (lock) , stereochemistry , organic chemistry , catalysis , biochemistry , aspirin , clopidogrel , ecology , biology
Tartrate salt of carbocyclic amine 2 is one of the key starting materials for the synthesis of Ticagrelor 1 . During the synthesis of 1 , the isomers of 2 also need to be considered as potential impurities and characterized before establishing the specification of product. In the present work, detailed study has been carried out to synthesize the related substances of 2 , and their structure characterization has been discussed.