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2‐Cyano‐ N ‐(thiophen‐2‐yl)acetamide in Heterocyclic Synthesis: Synthesis and Antibacterial Screening of Novel Pyrido[1,2‐ a ]thieno[3,2‐ e ]pyrimidine‐2‐carboxylate Moieties
Author(s) -
Abdelmoniem Amr M.,
Ghozlan Said A. S.,
Abdelwahab Hassan M.,
Abdelhamid Ismail A.
Publication year - 2019
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.3676
Subject(s) - chemistry , acetamide , piperidine , pyrimidine , pyridine , antibacterial activity , combinatorial chemistry , stereochemistry , medicinal chemistry , organic chemistry , bacteria , biology , genetics
A novel series of interesting 6,8‐dicyanopyrido[1,2‐ a ]thieno[3,2‐ e ]pyrimidine‐2‐carboxylate compounds were prepared via the reaction of readily accessible 2‐cyano‐ N ‐(thiophen‐2‐yl)acetamide with arylidene malononitriles in pyridine in the presence of piperidine. Biological screening of the tested compounds as antibacterial agents was also studied.