Premium
Efficient synthesis of 1,3,4‐thiadiazoles using hydrogen bond donor (thio)urea derivatives as organocatalysts
Author(s) -
Rostamizadeh Shahnaz,
Aryan Reza,
Reza Ghaieni Hamid,
Mohammad Amani Ali
Publication year - 2010
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.367
Subject(s) - thiourea , chemistry , thiadiazoles , thio , acetonitrile , steric effects , urea , hydrogen bond , proton nmr , catalysis , organic chemistry , combinatorial chemistry , medicinal chemistry , molecule
A simple and efficient procedure for the synthesis of 1,3,4‐thiadiazoles has been achieved using thiourea as organocatalyst. In this study, the steric and electronic effects using structurally different derivatives of urea and thiourea in different solvents were evaluated. The best yields and the rate of the reactions were obtained using 30 mol % of thiourea as catalyst in acetonitrile at room temperature. The molecular structures of the products were established by 1 H and 13 C NMR spectral data. J. Heterocyclic Chem., (2010).