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Synthesis of Structurally Diversified Benzo[ c ]chromene Derivatives under (An)aerobic Conditions Catalyzed by CuI
Author(s) -
Dong Fang,
Liu JianQuan,
Wang XiangShan
Publication year - 2019
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.3666
Subject(s) - chemistry , regioselectivity , catalysis , cyclohexane , proline , medicinal chemistry , coumarin , stereochemistry , organic chemistry , amino acid , biochemistry
2‐Bromobenzoic acids underwent an α ‐arylation with cyclohexane‐1,3‐diones to give 1 H ‐benzo[ c ]chromene‐1,6(2 H )‐diones under Ar atmosphere catalyzed by CuI/ l ‐proline in the presence of Cs 2 CO 3 . The subsequent regioselective oxidation took place under O 2 balloon automatically based on the substituents for the construction of structurally diversified benzo[ c ]coumarin derivatives.