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Diversified Synthetic Strategies for Pyrroloindoles: An Overview
Author(s) -
Manjal Sundeep Kaur,
Pathania Shelly,
Bhatia Rohit,
Kaur Ramandeep,
Kumar Kapil,
Rawal Ravindra K.
Publication year - 2019
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.3661
Subject(s) - chemistry , indole test , antifungal , drug discovery , combinatorial chemistry , scaffold , biochemical engineering , nanotechnology , computational biology , organic chemistry , biochemistry , computer science , biology , database , microbiology and biotechnology , engineering , materials science
In current scenario, heterocyclic compounds' role in medicinal chemistry has been tremendously increased as they possess wide number of pharmacological activities. One of the common heterocycles include indole skeleton with well‐established biological significance in field of medicinal chemistry. Fusion of indole nucleus with pyrrole heterocycle constitutes pyrroloindole scaffold, which further modifies the existing properties of indole alone. Pyrroloindole is a privileged scaffold found in various types of bioactive entities including natural compounds and exhibits wide variety of pharmacological activities like muscle relaxant, antifungal, antitumor, and antibiotic. Therefore, it is considered as attractive template for drug discovery. From several years, numbers of synthetic strategies have been reported for the synthesis of pyrroloindole and its derivatives, including also natural compounds such as amauromine, yuremamine, and chimonanthines. Here, in this review, we have tried to compile various synthetic strategies of pyrroloindole and its derivatives.