A Concise Stereoselective Synthesis of ( R )‐2‐Benzylmorpholine and ML398 from ( R )‐(−)‐2‐Phenylglycinol | Zendy

Torres Saúl | Zendy; Velasco Manuel | Zendy; GallegosRojas José Ángel | Zendy; Bernès Sylvain | Zendy; Orea María L. | Zendy; Terán Joel L. | Zendy; Huelgas Gabriela | Zendy; GómezCalvario Víctor | Zendy; Juárez Jorge R. | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Premium

A Concise Stereoselective Synthesis of ( R )‐2‐Benzylmorpholine and ML398 from ( R )‐(−)‐2‐Phenylglycinol

Author(s) -

Torres Saúl,

Velasco Manuel,

GallegosRojas José Ángel,

Bernès Sylvain,

Orea María L.,

Terán Joel L.,

Huelgas Gabriela,

GómezCalvario Víctor,

Juárez Jorge R.

Publication year - 2019

Publication title -

journal of heterocyclic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.321

H-Index - 59

eISSN - 1943-5193

pISSN - 0022-152X

DOI - 10.1002/jhet.3657

Subject(s) - stereoselectivity , chemistry , morpholine , alkylation , stereochemistry , combinatorial chemistry , organic chemistry , catalysis

We describe here an efficient stereoselective method for the preparation of ( R )‐2‐benzylmorpholine and ML398. The present method features a high diastereocontrol using an endocyclic oxidation of phenylglycinol‐derived morpholine and a stereoselective alkylation of chiral non‐racemic morpholin‐3‐one as key steps.

This content is not available in your region!

Continue researching here.

Having issues? You can contact us here

Accelerating Research