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A Facile and Effective Procedure for Synthesis of Polyfunctionalized Bis (imidazolyl) Pyrrole/Imidazolyl Indole from Pyrrole/Indole with Arylglyoxals and N ‐aryl amidines
Author(s) -
Masoudi Mozhgan,
ShahbaziManshadi Mohammad Reza,
AnaryAbbasinejad Mohammad
Publication year - 2019
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.3652
Subject(s) - chemistry , indole test , pyrrole , aryl , ethanol , combinatorial chemistry , organic chemistry , medicinal chemistry , alkyl
Heterocyclic systems containing bis (imidazolyl) pyrrole or imidazolyl indole moieties were synthesized by heterocyclization of pyrrole or indole with arylglyoxal monohydrates and N ‐aryl amidines in ethanol catalyzed by FeCl 3 at room temperature. The paper reports a facile, efficient, and environmentally friendly protocol for the synthesis of new products. Products were isolated by simple filtration, and their structures were established from their spectroscopic data.