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Efficient chemoselective alkylation of quinoline 2,4‐diol derivatives in water
Author(s) -
Ahmed Nafees,
Brahmbhatt Keyur G.,
Singh Inder P.,
Bhutani Kamlesh K.
Publication year - 2011
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.364
Subject(s) - chemistry , quinoline , aniline , alkylation , diol , diethyl malonate , organic chemistry , condensation , malonate , catalysis , physics , thermodynamics
Synthesis of various C‐3‐dialkyl derivatives of quinoline 2,4‐diol was achieved by condensation of aniline or substituted anilines with diethyl malonate, followed by chemoselective alkylation at C‐3 in water. The higher yields, easy work up and environmental compatible conditions are the main aspects of our method. J. Heterocyclic Chem., 2011.

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