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An Efficient Access to Pyrimidine‐based Polyfunctional Heterocycles with Anticipated Antibacterial Activity
Author(s) -
Mourad Asmaa Kamal,
Mohammed Fatehia K.,
Tammam Gamal Hassan,
Mohammed Shimaa Rabie
Publication year - 2019
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.3621
Subject(s) - chemistry , thiourea , nucleophile , antibacterial activity , pyrimidine , derivative (finance) , electrospray ionization , sodium ethoxide , electrophile , combinatorial chemistry , yield (engineering) , proton nmr , carbon 13 nmr , gram , organic chemistry , stereochemistry , catalysis , bacteria , ion , materials science , biology , ethanol , financial economics , metallurgy , economics , genetics
6‐Amino‐2‐thioxotetrahydropyrimidine‐5‐carbonitrile derivative 2 was synthesized in a good yield via refluxing a mixture of arylidene 1 and thiourea in a highly basic sodium ethoxide solution. Subsequently, the synthesized pyrimidine‐2‐thione derivative 2 was allowed to interact with diversified nucleophiles and electrophiles under various reaction conditions in order to have a feasible access to further new and assorted fused heterocycles. Finally, the biological activity of the newly synthesized fused pyrimidines was screened in vitro against four different Gram‐positive and Gram‐negative bacterial strains. All the developed heterocycles were adequately characterized utilizing 1 H‐NMR, 13 C‐NMR, Fourier transform infrared, elemental analysis, and electrospray ionization–mass spectrum and tested for their antibacterial activity.