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A Catalytic Route to Pyrrole Derivatives via Copper‐catalyzed Multicomponent Reaction
Author(s) -
SamzadehKermani Alireza,
Ghasemi Samira
Publication year - 2019
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.3614
Subject(s) - chemistry , malononitrile , catalysis , regioselectivity , alkyl , anhydrous , aryl , pyrrole , reaction conditions , organic chemistry , medicinal chemistry , combinatorial chemistry
A novel approach for the synthesis of pyrrole derivatives has been reported. The reactions starting from terminal alkynes, carbodiimides, and malononitrile using CuI, DBU, and TBPAc in anhydrous MeCN afforded the functionalized pyrroles in acceptable yields. Alkyl‐, aryl‐, and heteroaromatic terminal alkynes were tolerated. Carbodiimides could be symmetrical and unsymmetrical substrates with aryl or alkyl substituents. The reaction exhibited a good regioselectivity when unsymmetrical carbodiimides were employed.