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POCl 3 ‐Mediated Reaction: A New Entry to Polysubstituted 2‐Pyridones via Self‐condensation of β‐Keto Amides
Author(s) -
Gao Baochang,
Sun Yufeng,
Wang Jun,
Cao Chang,
Yuan Zhigang,
Tian Yuan,
Shi Yu,
Liu Wenbin
Publication year - 2019
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.3613
Subject(s) - chemistry , condensation , intramolecular force , nucleophile , condensation reaction , combinatorial chemistry , self condensation , reaction conditions , transformation (genetics) , organic chemistry , catalysis , condensation polymer , physics , biochemistry , gene , thermodynamics
Synthesis of polysubstituted 2‐pyridones and their analogues from β‐keto amides via self‐condensation cyclization is described. Notable advantages include mild reaction conditions, reduced synthetic steps, high yields, and a readily available starting materials. Further mechanistic studies suggest that the transformation proceeds through self‐condensation, intramolecular nucleophilic cyclization, and elimination.