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Synthesis of Novel 1,2,4‐Triazole‐3‐thione Derivatives as Influenza Neuraminidase Inhibitors
Author(s) -
Liu Ling,
Ye Jiao,
Xiao Mengwu,
Yuan Keyang,
He Mei,
Hu Aixi,
Jia Hao,
Liu Ailin
Publication year - 2019
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.3612
Subject(s) - chemistry , neuraminidase , potency , triazole , neuraminidase inhibitor , in vitro , docking (animal) , stereochemistry , 1,2,4 triazole , structure–activity relationship , 1,2,3 triazole , combinatorial chemistry , enzyme , biochemistry , medicinal chemistry , organic chemistry , covid-19 , medicine , nursing , disease , pathology , infectious disease (medical specialty)
A series of 1,2,4‐triazole‐3‐thione derivatives ( 6a – 6t ) were synthesized and evaluated against influenza viruses (H1N1) neuraminidase (NA) in vitro . Eighteen compounds exhibited inhibitory potency with IC 50 values ranging from 14.68 ± 0.49 to 39.85 ± 4.23 μg/mL. Among them, compounds 6e and 6h showed significant inhibitory activity with IC 50 values of 14.97 ± 0.70 and 14.68 ± 0.49 μg/mL, respectively. Structure activity relationships were established. Molecular docking studies were performed to understand the binding interaction between active compounds and NA.