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Synthesis of some novel N ‐alkyl/acyl/aroyl 2‐(chroman/6‐bromochroman‐2‐yl)‐1 H ‐benzimidazoles using ionic liquids and their antibacterial activity
Author(s) -
Raut Changdev Namdev,
Bagul Sandeep Madhukar,
Janrao Ravindra Ashok,
Vaidya Sanjay Dashrath,
Kumar Bobba Venkata Siva,
Mahulikar Pramod Pandurang
Publication year - 2010
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.360
Subject(s) - chemistry , hexafluorophosphate , ionic liquid , tetrafluoroborate , benzimidazole , electrophile , antibacterial activity , medicinal chemistry , alkyl , organic chemistry , catalysis , bacteria , biology , genetics
ynthesis of some novel N ‐substituted 2‐(chroman/6‐bromochroman‐2‐yl)‐1 H ‐benzimidazoles by the condensation of 3,4‐dihydro‐2 H ‐chroman‐2‐carboxylic acid and 6‐bromo‐3,4‐dihydro‐2 H ‐chroman‐2‐carboxylic acid with o ‐phenylenediamine in ionic liquid (IL) [bmim]BF 4 and subsequent reactions at the benzimidazole‐NH with different types of electrophiles in ILs [bmim]BF 4 = 1‐butyl‐3‐methylimidazolium tetrafluoroborate, [bmim]PF 6 = 1‐butyl‐3‐methylimidazolium hexafluorophosphate and [buPy]BF 4 = butylpyridinium tetrafluoroborate in the presence of sodium hydroxide as a base have been reported. All the synthesized compounds were screened for their antibacterial activity . Some compounds exhibited promising antibacterial activity against Staphylococcus aureus and Salmonella typhimurium when compared to Cephalexin as a reference standard. J. Heterocyclic Chem., (2010).
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