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Ultrasound‐Assisted Facile Synthesis and Antimicrobial Studies of Alkanediyl‐bis‐thiazolidin‐4‐ones and Alkanediyl‐bis‐thiazinan‐4‐ones
Author(s) -
Kaur Amritpal,
Kaur Avneet Pal,
Gautam Poonam,
Gautam Deepika,
Chaudhary Ram Pal
Publication year - 2019
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.3590
Subject(s) - chemistry , aryl , thiazolidine , combinatorial chemistry , medicinal chemistry , organic chemistry , alkyl
Alkanediyl‐bis‐2‐aryl‐thiazolidin‐4‐one and alkanediyl‐bis‐2‐aryl‐1,3‐thiazinan‐4‐one derivatives have been congregated in a single step reaction of diaminoalkanes, aryl aldehydes, and sulfanyl acids in the presence of coupling agent N , N ′‐dicyclohexylcarbodiimide under ultrasonic conditions. This method of constructing 4‐keto derivatives of thiazolidine and thiazinane is quick and clean besides yielding the products in quantitative yields. The spectral techniques corroborated the structures of the isolated products. Biological assay of the synthesized products has also been reported.