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An Efficient Method for the Synthesis of N ‐uracil‐4‐oxo‐thiazolidines without Catalyst
Author(s) -
Mohamed Asmaa H.,
Shaker Raafat M.
Publication year - 2019
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.3589
Subject(s) - thioglycolic acid , chemistry , uracil , catalysis , chloride , elemental analysis , organic chemistry , combinatorial chemistry , dna , biochemistry
We have developed highly efficient, one‐pot three component reaction of 5‐amino‐uracil and aromatic aldehydes with thioglycolic acid for the synthesis of N‐uracil‐thiazolidinones in excellent yields. The same products were also prepared by the reaction of Schiff bases of 5‐amino‐uracil with thioglycolic acid. In addition, benzylation of thiazolidinone derivatives and Schiff bases by using benzyl chloride was investigated. The results obtained from elemental microanalysis and different spectral data are in agreement with the assigned structures.