Premium
Synthesis of Some Substituted Pyrazolopyrimidine Derivatives: An Environmentally Benign Approach
Author(s) -
Pathak Arpit Kumar,
Gupta Sharoni,
Punjabi Pinki B.,
Ameta Garima,
Ameta Chetna
Publication year - 2019
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.3587
Subject(s) - chemistry , antifungal , diethyl malonate , bromide , microwave irradiation , organic chemistry , elemental analysis , combinatorial chemistry , environmentally friendly , ionic liquid , medicine , dermatology , catalysis , ecology , biology
Pyrazolopyrimidines constitute a medicinally important class of heterocyclic compounds. Herein, we report an efficient and environmentally benign method for the synthesis of pyrazolo[3,4‐ d ]pyrimidin‐3‐ones from 2,4‐dinitrophenylhydrazine and diethyl malonate under microwave irradiation in 1,3‐dibutylimidazolium bromide ionic liquid. The synthesized compounds were analyzed by elemental analysis and standard spectroscopic techniques. The compounds were screened for their antibacterial and antifungal activities.