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Green Approach for the Synthesis of a New Class of Diamidomethane‐linked Benzazolyl Pyrazoles and Evaluation as Antifungals
Author(s) -
Sowdari Jyothi,
Gudi Yamini,
Donthamsetty Sowmya V.,
Venkatapuram Padmavathi,
Adivireddy Padmaja
Publication year - 2019
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.3569
Subject(s) - chemistry , nitrile , antifungal , bromide , imine , proton nmr , organic chemistry , combinatorial chemistry , carbon 13 nmr , medicine , dermatology , catalysis
A new class of diamidomethane‐linked benzoxazolyl pyrazoles, benzothiazolyl pyrazoles, and benzimidazolyl pyrazoles were synthesized from the synthetic intermediates N ‐benzazolylcarbamoylmethylcinnamides adopting environmentally benign methods. In fact, nitrile imine was generated from araldehyde phenylhydrazone in the presence of iodosobenzene and cetyltrimethylammonium bromide followed by oxidation with iodine in dimethylsulfoxide. The structures of compounds were characterized by IR, 1 H NMR, 13 C NMR, and mass spectra. The title compounds were also evaluated for their antifungal activity. Amongst all the tested compounds benzimidazolyl pyrazolyl carboxamides ( 13a and 13b ) were found to be potential antifungal agents.