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Synthesis, Antimicrobial Evaluation, and Docking Studies of Substituted Acetylphenoxymethyl‐triazolyl‐ N ‐phenylacetamides
Author(s) -
Phatak Pramod S.,
Sathe Bhaurao P.,
Dhumal Sambhaji T.,
Rehman Naziya N. M. A.,
Dixit Prashant P.,
Khedkar Vijay M.,
Haval Kishan P.
Publication year - 2019
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.3568
Subject(s) - chemistry , antimicrobial , docking (animal) , combinatorial chemistry , dna gyrase , click chemistry , stereochemistry , triazole , in vitro , protein data bank (rcsb pdb) , molecule , antibacterial activity , biochemistry , bacteria , organic chemistry , escherichia coli , genetics , nursing , biology , gene , medicine
A series of molecules containing acetylphenoxymethyl, triazole, and N ‐phenylacetamide moieties were synthesized via the click chemistry approach. All the synthesized compounds were screened for their antimicrobial activities in vitro . The synthesized compounds 8a , 8b , 8m , and 8n showed better activities. We further performed exploratory docking studies to gain some insight regarding the molecular mechanism of antibacterial action of these compounds that could guide further structure‐activity relationship (SAR) studies. We examined the interaction of the most active compound with DNA gyrase (pdb id:1KZN). Based on antimicrobial and docking studies, the compounds 8a , 8b , 8m , and 8n were identified as potential antimicrobial agents.