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Synthesis of Novel Trifluoromethyl Group Containing Pyrido Furo/Thieno Pyrimidinone Derivatives and Their Anticancer Activity
Author(s) -
Racha Hanumandlu,
Vadla Balakishan,
Peddolla Kavitha,
Betala Sailu
Publication year - 2019
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.3566
Subject(s) - chemistry , trifluoromethyl , hela , trifluoroacetic acid , pyridine , amide , cancer cell lines , stereochemistry , combinatorial chemistry , cancer cell , medicinal chemistry , alkyl , cancer , organic chemistry , cell , biochemistry , medicine
A series of novel trifluoromethyl group containing pyridofuro/thieno pyrimidinone derivatives 5a–p were prepared starting from 2‐oxo/thioxo‐6‐phenyl/thien‐2‐yl‐4‐(trifluoromethyl)‐1,2‐dihydropyridine‐3‐carbonitrile 1 compound on reaction with bromoethylacetate and further different primary aliphatic amines, under their refluxing conditions to afford amide tagged furo/thieno pyridine derivatives 4 . Compound 4 on reaction with trifluoroacetic acid and obtained novel trifluoromethyl group containing pyridofuro/thieno pyrimidinone derivatives 5a–p . All the synthesized compounds 5a–p were tested for anticancer activity on four cancer cell lines such as HeLa cervical cancer (CCL‐2), COLO 205 colon cancer (CCL‐222), HepG2 liver cancer (HB‐8065), MCF7 breast cancer (HTB‐22), and one normal cell line (HEK 293); compounds 5m , 5n , and 5p are found to be more promising anticancer activity at micromolar concentration and found to be nontoxic on normal cell line.