Synthesis and Screening of Phosphodiesterase 5 Inhibitory Activity of Fused and Isolated Triazoles Based on Thieno[2,3‐ d ]pyrimidines | Zendy

Ameen Mohamed A. | Zendy; Ahmed Essam Kh. | Zendy; Mahmoud Hemdan I. | Zendy; Ramadan Mohamed | Zendy

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Synthesis and Screening of Phosphodiesterase 5 Inhibitory Activity of Fused and Isolated Triazoles Based on Thieno[2,3‐ d ]pyrimidines

Author(s) -

Ameen Mohamed A.,

Ahmed Essam Kh.,

Mahmoud Hemdan I.,

Ramadan Mohamed

Publication year - 2019

Publication title -

journal of heterocyclic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.321

H-Index - 59

eISSN - 1943-5193

pISSN - 0022-152X

DOI - 10.1002/jhet.3560

Subject(s) - chemistry , phosphodiesterase , inhibitory postsynaptic potential , combinatorial chemistry , stereochemistry , sildenafil , cgmp specific phosphodiesterase type 5 , organic chemistry , enzyme , medicine , neuroscience , biology

Novel fused and isolated triazoles based on thieno[2,3‐ d ]pyrimidines were synthesized starting from 2‐aminothiophene ester and structurally confirmed by spectral and analytical data. The synthesized triazolo compounds were screened for their phosphodiesterase 5 inhibitory activity and showed encouraging activity than did sildenafil as a reference drug.

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