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Synthesis and Screening of Phosphodiesterase 5 Inhibitory Activity of Fused and Isolated Triazoles Based on Thieno[2,3‐ d ]pyrimidines
Author(s) -
Ameen Mohamed A.,
Ahmed Essam Kh.,
Mahmoud Hemdan I.,
Ramadan Mohamed
Publication year - 2019
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.3560
Subject(s) - chemistry , phosphodiesterase , inhibitory postsynaptic potential , combinatorial chemistry , stereochemistry , sildenafil , cgmp specific phosphodiesterase type 5 , organic chemistry , enzyme , medicine , neuroscience , biology
Novel fused and isolated triazoles based on thieno[2,3‐ d ]pyrimidines were synthesized starting from 2‐aminothiophene ester and structurally confirmed by spectral and analytical data. The synthesized triazolo compounds were screened for their phosphodiesterase 5 inhibitory activity and showed encouraging activity than did sildenafil as a reference drug.