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Synthesis and Anticancer Evaluation of Some Novel Quinazolin‐4(3 H )‐one Derivatives
Author(s) -
Gouhar Rasha S.,
Haneen David S. A.,
ElHallouty Salwa M.
Publication year - 2019
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.3559
Subject(s) - chemistry , thiourea , quinazolinone , malononitrile , ammonium acetate , hydrazine (antidepressant) , pyrazole , pyridine , hydrate , pyrimidine , cancer cell lines , ketone , urea , organic chemistry , combinatorial chemistry , stereochemistry , cancer cell , cancer , medicine , high performance liquid chromatography , chromatography , catalysis
A new series of quinazolinone derivatives bearing pyridine, pyrimidine, pyrazole, or pyran moieties were synthesized for the purpose of anticancer cell line evaluation. Synthesis of these derivatives was achieved by the reaction of the ketone 2 with the appropriate aldehydes in the presence of either ethylcyanoacetate or malononitrile and ammonium acetate in one‐pot reaction. Chalcones 6 reacted also with hydrazine hydrate to give the corresponding pyrazolines 7 and reacted with urea or thiourea to give the 2‐oxopyrimidines or the 2‐thioxopyrimidines 8 , respectively. Evaluation of some representative examples of the newly synthesized compounds against cancer cell lines showed promising activity as anticancer agents.