Multi‐component Reactions, Solvent‐free Synthesis of Substituted Pyrano‐pyridopyrimidine under Different Conditions Using ZnO Nanoparticles | Zendy

Mahmoud Naglaa F. H. | Zendy; ElSaghier Ahmed M. | Zendy

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Multi‐component Reactions, Solvent‐free Synthesis of Substituted Pyrano‐pyridopyrimidine under Different Conditions Using ZnO Nanoparticles

Author(s) -

Mahmoud Naglaa F. H.,

ElSaghier Ahmed M.

Publication year - 2019

Publication title -

journal of heterocyclic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.321

H-Index - 59

eISSN - 1943-5193

pISSN - 0022-152X

DOI - 10.1002/jhet.3556

Subject(s) - malononitrile , chemistry , pyrimidine , yield (engineering) , catalysis , environmentally friendly , solvent , condensation , nanoparticle , component (thermodynamics) , condensation reaction , organic chemistry , green chemistry , elemental analysis , proton nmr , combinatorial chemistry , chemical engineering , reaction mechanism , stereochemistry , ecology , materials science , thermodynamics , physics , metallurgy , biology , engineering

2‐Amino‐4‐(4‐substitutedphenyl)‐5‐oxo‐4 H ,5 H ‐pyrano[2,3 ‐d ]pyrido[1,2 ‐a ]pyrimidine‐3‐carbonitrile‐derivatives 2–12 were synthesized via multi‐component condensation reactions of different aromatic aldehydes, 3 H ‐pyrido[1,2 ‐a ]pyrimidine‐2,4‐dione 1 , and malononitrile by using ZnO nanoparticles as green chemistry, environmentally friendly catalyst under solvent‐free conditions. The present work creates a variety of biologically active heterocyclic compounds in excellent yield and a short time. The structures of all synthesized compounds were elucidated with the elemental analyses, IR, 1 H NMR, and mass spectral data.

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