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Multi‐component Reactions, Solvent‐free Synthesis of Substituted Pyrano‐pyridopyrimidine under Different Conditions Using ZnO Nanoparticles
Author(s) -
Mahmoud Naglaa F. H.,
ElSaghier Ahmed M.
Publication year - 2019
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.3556
Subject(s) - malononitrile , chemistry , pyrimidine , yield (engineering) , catalysis , environmentally friendly , solvent , condensation , nanoparticle , component (thermodynamics) , condensation reaction , organic chemistry , green chemistry , elemental analysis , proton nmr , combinatorial chemistry , chemical engineering , reaction mechanism , stereochemistry , ecology , materials science , thermodynamics , physics , metallurgy , biology , engineering
2‐Amino‐4‐(4‐substitutedphenyl)‐5‐oxo‐4 H ,5 H ‐pyrano[2,3 ‐d ]pyrido[1,2 ‐a ]pyrimidine‐3‐carbonitrile‐derivatives 2–12 were synthesized via multi‐component condensation reactions of different aromatic aldehydes, 3 H ‐pyrido[1,2 ‐a ]pyrimidine‐2,4‐dione 1 , and malononitrile by using ZnO nanoparticles as green chemistry, environmentally friendly catalyst under solvent‐free conditions. The present work creates a variety of biologically active heterocyclic compounds in excellent yield and a short time. The structures of all synthesized compounds were elucidated with the elemental analyses, IR, 1 H NMR, and mass spectral data.