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Highly Efficient One‐Pot Three‐Component Synthesis and Antimicrobial Activity of 2‐Amino‐4 H ‐chromene Derivatives
Author(s) -
Aminkhani Ali,
Talati Mina,
Sharifi Roholah,
Chalabian Firouzeh,
Katouzian Fatemeh
Publication year - 2019
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.3555
Subject(s) - chemistry , malononitrile , triethylamine , antimicrobial , enterococcus faecalis , bacillus subtilis , bacteria , minimum inhibitory concentration , antibacterial activity , staphylococcus aureus , orcinol , catalysis , organic chemistry , combinatorial chemistry , escherichia coli , biochemistry , genetics , biology , gene
A remarkably efficient three‐component reaction to synthesize 2‐amino‐4 H ‐chromenes derivatives from malononitrile, various aromatic aldehydes, and orcinol was described at room temperature in CH 2 Cl 2 in the presence of catalytic amount of triethylamine. In a facile one‐pot procedure, excellent yields of products were achieved in less than 1 h. Some of the synthesized 2‐amino‐4 H ‐chromenes derivatives demonstrated potent antibacterial activities against Gram‐positive bacteria including Staphylococcus aureus and Bacillus anthracis , indicated by disk method, minimum inhibitory concentration, and minimum bactericidal concentration approaches. However, none of the tested compounds expressed any antibacterial activities against Enterococcus faecalis and Gram‐negative bacteria.