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Multicomponent One‐pot Synthesis of Oxadiazole Included Pyranopyrazoles as Promising Antioxidant Agents
Author(s) -
Reddy Guda Mallikarjuna,
Yun Chen Di,
Venkata Subbaiah Munagapati,
Jianyou Long,
Wen JetChau
Publication year - 2019
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.3553
Subject(s) - chemistry , antioxidant , context (archaeology) , oxadiazole , combinatorial chemistry , novelty , catalysis , organic chemistry , environmentally friendly , paleontology , ecology , philosophy , theology , biology
Oxadiazole‐fused combinations are of great concern for the novelty of effective therapeutic agents. In this context, a series of oxadiazole included pyranopyrazoles were prepared under eco‐friendly synthetic way by using montmorillonite k10 as a catalyst. All the final outcomes were formed with good yields. Further, compounds screened for their antioxidant assay. Most of the compounds revealed promising activity. Among all outcomes, electron rich‐substituted compounds at para position demonstrated higher antioxidant activity than their corresponding ortho ‐substituted compounds. All belongings concluded that this eco‐friendly path is preferable to prepare therapeutic compounds. Further, biotic results established that all these biologically active compounds fit for supplementary to develop exogenous antioxidant drugs.