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A Convenient Synthetic Route of Diethyl (4‐Oxo‐chromeno[2,3‐ d ]pyrimidin‐2(5)‐yl)phosphonates
Author(s) -
Ali Tarik E.,
Assiri Mohammed A.,
Hassanin Noha M.,
Yahia I. S.,
Hussien Mai S. A.
Publication year - 2019
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.3550
Subject(s) - chemistry , phosphonate , dimethylformamide , acetal , enantiomer , medicinal chemistry , reaction conditions , organic chemistry , combinatorial chemistry , catalysis , solvent
Novel diethyl (4‐oxo‐3,4‐dihydro‐2 H ‐chromeno[2,3‐ d ]pyrimidin‐2‐yl)phosphonate as two enantiomers and diethyl (4‐oxo‐1,5‐dihydro‐4 H ‐chromeno[2,3‐ d ]pyrimidin‐5‐yl) phosphonate were obtained in easy procedure via reaction of 2‐imino‐2 H ‐chromene‐3‐carboxamide, dimethylformamide dimethyl‐acetal, and diethyl phosphite in a simple one pot. Possible reaction mechanisms were proposed. The structures of the obtained products were confirmed by elemental analyses and spectral tools.

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