Premium
Pyrimidine Derivatives with Terminal Pyridyl Heterocycles: Facile Synthesis and Their Antiproliferative Activities
Author(s) -
Singh Khushwant,
Jana Achintya,
Lippmann Petra,
Ott Ingo,
Das Neeladri
Publication year - 2019
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.3547
Subject(s) - chemistry , pyrimidine , pyridine , molecule , combinatorial chemistry , cytotoxicity , mass spectrometry , stereochemistry , in vitro , organic chemistry , biochemistry , chromatography
Incorporation of heterocyclic pyrimidine or pyridine motifs is common in the drug design for various therapeutic applications. Herein, we describe the facile synthesis of two molecules containing both pyrimidine and pyridine scaffolds. A variety of analytical techniques (multinuclear NMR, Fourier transform infrared, and mass spectrometry analyses) confirmed the purity of these molecules. In pristine form, their potential as antitumor drugs was screened by investigating their cytotoxicity against various cell lines (cancerous and normal cells). Experimental results confirmed that the two molecules exhibited cell growth inhibition at very low concentrations. This was evident from their IC 50 values that are in the range of 0.45–2.20 μM.