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Design, Synthesis, and Evaluation of Some Novel Heterocycles Bearing Pyrazole Moiety as Potential Anticancer Agents
Author(s) -
Abdelgawad Nancy,
Ismail Mahmoud F.,
Hekal Mohamed H.,
Marzouk Magda I.
Publication year - 2019
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.3544
Subject(s) - chemistry , malononitrile , pyrazole , moiety , ethyl acetoacetate , ethyl cyanoacetate , diethyl malonate , semicarbazide , malonate , combinatorial chemistry , cinnamaldehyde , organic chemistry , catalysis
1,3‐Diphenylpyrazole‐4‐carboxylaldehyde and o ‐hydroxyacetophenone were exploited as starting materials for the synthesis of novel substituted chalconated pyrazole derivative. The proclivity of this compound towards carbon and nitrogen nucleophiles such as malononitrile, diethyl malonate, ethyl cyanoacetate, ethyl acetoacetate, semicarbazide, thiosemicarbazide, and hydroxylamine has been investigated. The structures of all synthesized compounds were ascertained by analytical and spectral data. The antitumor activity of the target synthesized compounds was tested against a panel of two human tumor cell lines, namely, hepatocellular carcinoma (liver) HepG2 and mammary gland breast MCF‐7.