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Synthesis of Pyrano[3,2‐ c ]quinoline‐3‐carboxaldehyde and 3‐(Ethoxymethylene)‐pyrano[3,2‐ c ]quinolinone and Their Chemical Behavior toward Some Nitrogen and Carbon Nucleophiles
Author(s) -
Othman Elham S.,
Hassanin Hany M.,
Mostafa Mai A.
Publication year - 2019
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.3539
Subject(s) - chemistry , quinoline , yield (engineering) , reagent , nucleophile , methylene , reactivity (psychology) , organic chemistry , medicinal chemistry , stereochemistry , catalysis , medicine , materials science , alternative medicine , pathology , metallurgy
Synthesis of novel 3‐(ethoxymethylene)‐pyrano[3,2‐ c ]quinolinone and pyrano[3,2‐ c ]quinoline‐3‐carboxaldehyde was accomplished efficiently via a simple method. These two scaffolds were used as precursors to afford new biologically interesting products in good yield and short reaction times. The chemical reactivity of ethoxy methylene 2 and carboxaldehyde 3 toward different nucleophilic reagents was studied. Structures of the new synthesized compounds were elucidated by their analytical and spectral data.