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Facile Synthesis of Novel Aminopyrrolobenzimidazole System via Regioselective Amination
Author(s) -
Salameh Bader A.,
Mahmoud Haneen,
Khanfar Monther A.,
AlQawasmeh Raed A.
Publication year - 2019
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.3528
Subject(s) - regioselectivity , chemistry , amination , nucleophile , amine gas treating , diamine , chlorine atom , chlorine , combinatorial chemistry , phenylene , organic chemistry , deoxygenation , medicinal chemistry , catalysis , polymer
A new series of substituted pryrrolobenzimidazoles have been prepared via regioselective displacement of chlorine atom from dichloropyrrolobenzimidazoles with various amine nucleophiles. The dichloro compounds were obtained from the reaction of ortho phenylene diamine compounds with dichloromaleic anhydride.