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An Efficient and Facile Synthesis of tert ‐Butyl 2‐(Methylamino)‐3‐nitro‐5‐oxo‐4‐aryl‐7,8‐dihydro‐4 H ‐pyrano[3,2‐ c ]pyridine‐6(5 H )‐carboxylate derivatives in [BMIM]BF 4
Author(s) -
Pan Zhengbing,
Xu Hui,
Mao Kaimin,
Dai Lei,
Zhao Liming,
Rong Liangce
Publication year - 2019
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.3517
Subject(s) - chemistry , pyridine , nitro , amine gas treating , aryl , medicinal chemistry , reaction conditions , organic chemistry , combinatorial chemistry , catalysis , alkyl
In this research, we have developed an efficient three‐component reaction for the synthesis of pyrano[3,2‐ c ]pyridine derivatives from the reaction of aromatic aldehydes, tert ‐butyl 2,4‐dioxopiperidine‐1‐carboxylate, and N ‐methyl‐1‐(methylthio)‐2‐nitroethylen‐1‐amine in [BMIM]BF 4 medium. The advantages of this method were readily available starting materials, simple reaction conditions, and satisfactory yields.

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