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Synthesis and Fungicidal Activities of 2,3‐Dimethyl‐4‐(1‐acyloxy)alkoxy‐6‐ tert ‐butyl‐8‐fluoroquinolines
Author(s) -
Pei Dan,
Zhang Fan,
Liu Jie,
Zhang DongLin,
Yang Ren,
Zhong LiangKun,
Tan ChengXia,
Xu TianMing
Publication year - 2019
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.3515
Subject(s) - chemistry , alkoxy group , acylation , hydrolysis , proton nmr , aniline , medicinal chemistry , organic chemistry , carbon 13 nmr , fungicide , alkyl , botany , biology , catalysis
A series of 2,3‐dimethyl‐4‐(1‐acyloxy)alkoxy‐6‐ tert ‐butyl‐8‐fluoroquinolines were synthesized by 4‐( tert ‐butyl)aniline as the starting material via acylation, substitution, and hydrolysis, and their structures were characterized by 1 H NMR, 13 C NMR, and HRMS. The fungicidal activity showed that compounds 6c , 6e , and 6f had excellent activity against Sphoaerotheca fuliginea with EC 50 values of 38.62, 6.77, and 50.35 mg/L, respectively. The results suggest that this chemotype of compounds warrant further studies as promising fungicide.