Premium
Synthesis of Lamellarin Q Analogues as Potential Antibiofilm Compounds
Author(s) -
PraudTabariès Annie,
Bottzeck Olivier,
Blache Yves
Publication year - 2019
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.3512
Subject(s) - chemistry , stereochemistry , combinatorial chemistry , catalysis , computational chemistry , organic chemistry
An efficient synthesis of lamellarin Q analogues is described. This involves a two‐step procedure through a “Cu‐catalyzed” 1,3‐cycloaddtion and a “Pd‐catalyzed” arylation allowing high degrees of chemical diversity in view of structure–activity relationship studies in the field of antibiofilm activities.