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Highly Efficient Direct Synthesis of Scaffold 9a,10,12,12a‐Tetrahydrobenzo[ b ]cyclopenta[ f ]pyrrolo[1,2‐ d ][1,4]diazepinone by Using Active Phoshomolybdic Acid
Author(s) -
Sarnikar Yuvaraj P.,
Biradar Dhanraj O.,
Mane Yogesh D.,
Khade Bhimrao C.
Publication year - 2019
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.3500
Subject(s) - chemistry , phosphomolybdic acid , aniline , methanol , aryl , combinatorial chemistry , substrate (aquarium) , domino , medicinal chemistry , stereochemistry , organic chemistry , catalysis , alkyl , oceanography , geology
Domino coupling of furan‐2‐yl (phenyl) methanol and 2‐(1 H ‐pyrrol‐1‐yl) aniline has been achieved in the presence of 10 mol% phosphomolybdic acid in CH 3 CN under reflux to afford the corresponding biologically active 10‐aryl‐9a,10,12,12a‐tetrahydrobenzo[ b ]cyclopenta[ f ]pyrrolo[1,2‐ d ][1,4]diazepin‐11(9 H )‐ones in good yields. Broad substrate scope, short reaction times, environmentally benign, and operational simplicity makes this method more attractive.