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Design and Synthesis of Some New Analgesic Azole Derivatives Containing Tramadol Moiety
Author(s) -
Khodairy Ahmed,
Ahmed Eman A.,
Ismael Mohamed,
Mohamed Khaled M.,
Thabet Shymaa A.
Publication year - 2019
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.3492
Subject(s) - chemistry , oxazole , azole , thiazole , moiety , imidazole , hydrazide , acetic acid , hydrazine (antidepressant) , combinatorial chemistry , organic chemistry , stereochemistry , antifungal , medicine , dermatology , chromatography
Some new triazole, thiadiazole, oxadiazole, thiazole, oxazole, and imidazole derivatives have been synthesized via the reaction of tramadol bearing a hydrazide, hydrazine carbodithioate, and/or acetic acid group with certain reagents. Molecular docking study had been carried out to demonstrate the reactivity of these synthetic compounds for interaction with Cytochrome P450 2D6 ( CYP2D6 ).