Design and Synthesis of Some New Analgesic Azole Derivatives Containing Tramadol Moiety | Zendy

Khodairy Ahmed | Zendy; Ahmed Eman A. | Zendy; Ismael Mohamed | Zendy; Mohamed Khaled M. | Zendy; Thabet Shymaa A. | Zendy

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Design and Synthesis of Some New Analgesic Azole Derivatives Containing Tramadol Moiety

Author(s) -

Khodairy Ahmed,

Ahmed Eman A.,

Ismael Mohamed,

Mohamed Khaled M.,

Thabet Shymaa A.

Publication year - 2019

Publication title -

journal of heterocyclic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.321

H-Index - 59

eISSN - 1943-5193

pISSN - 0022-152X

DOI - 10.1002/jhet.3492

Subject(s) - chemistry , oxazole , azole , thiazole , moiety , imidazole , hydrazide , acetic acid , hydrazine (antidepressant) , combinatorial chemistry , organic chemistry , stereochemistry , antifungal , medicine , dermatology , chromatography

Some new triazole, thiadiazole, oxadiazole, thiazole, oxazole, and imidazole derivatives have been synthesized via the reaction of tramadol bearing a hydrazide, hydrazine carbodithioate, and/or acetic acid group with certain reagents. Molecular docking study had been carried out to demonstrate the reactivity of these synthetic compounds for interaction with Cytochrome P450 2D6 ( CYP2D6 ).

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