Premium
New 1,3,4‐Thiadiazole Derivatives: Synthesis, Characterization, and Antimicrobial Activity
Author(s) -
AboBakr Ahmed M.,
Hashem Heba E.
Publication year - 2019
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.3489
Subject(s) - chemistry , triethyl orthoformate , malononitrile , acetophenone , carbon disulfide , cyclohexanone , isatin , yield (engineering) , carbon 13 nmr , phenyl isothiocyanate , antimicrobial , organic chemistry , knoevenagel condensation , proton nmr , medicinal chemistry , catalysis , materials science , metallurgy
In the present study, 2,5‐bis(mercapto‐acetichydrazide)‐1,3,4‐thiadiazole ( 1 ) was utilized by different reagents, namely, ethoxymethylene malononitrile, ethoxymethylene ethyl cyanoacetate, triethyl orthoformate, phenyl isothiocyanate, carbon disulfide, isatin, acetophenone, cyclohexanone, different aldehydes, and different anhydrides, to yield a new series of 2,5‐disubstituted‐1,3,4‐thiadiazoles 2 – 18 . The chemical structure of these products was characterized by the spectral data IR, 1 H‐NMR, 13 C‐NMR, MS, and elemental analysis. All the synthesized compounds were screened for their antibacterial activity.