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Synthesis, Characterization, and Antimicrobial Properties of New 1,3,4‐Thiadiazoles Derived from Azo Dyes
Author(s) -
Gür Mahmut
Publication year - 2019
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.3480
Subject(s) - thiadiazoles , benzothiazole , chemistry , antimicrobial , proton nmr , fourier transform infrared spectroscopy , elemental analysis , organic chemistry , carbon 13 nmr , combinatorial chemistry , nuclear chemistry , quantum mechanics , physics
Some new 1,3,4‐thiadiazoles derived from azo dyes were synthesized. Two different synthesis methods were used for these compounds: Esters pertaining to the azo dyes were converted into 1,3,4‐thiadiazoles, or benzothiazole ester derivatives were converted to 1,3,4‐thiadiazoles followed by the synthesis of azo dye derivatives. The desired products were successfully obtained using the latter method. The molecular structures of these compounds were characterized using spectroscopic methods such as FTIR, 1 H NMR, 13 C NMR, and elemental analysis. Furthermore, antimicrobial activity was studied for the synthesized compounds. Compound 3e exhibited antimicrobial activity against three different microorganisms. Compounds 3a , 3b , and 3d had activity against two different microorganisms, while compound 3c showed activity against only one microorganism.