Novel One‐Pot Synthesis of Functionalized Quinolines from Isocyanides, Aniline, and Acetylene Dicarboxylate  via  Cu‐Catalyzed Intramolecular C─H Activation Reactions | Zendy

Nematpour Manijeh | Zendy; Rezaee Elham | Zendy; Jahani Mehdi | Zendy; Tabatabai Sayyed Abbas | Zendy

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Novel One‐Pot Synthesis of Functionalized Quinolines from Isocyanides, Aniline, and Acetylene Dicarboxylate via Cu‐Catalyzed Intramolecular C─H Activation Reactions

Author(s) -

Nematpour Manijeh,

Rezaee Elham,

Jahani Mehdi,

Tabatabai Sayyed Abbas

Publication year - 2019

Publication title -

journal of heterocyclic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.321

H-Index - 59

eISSN - 1943-5193

pISSN - 0022-152X

DOI - 10.1002/jhet.3477

Subject(s) - chemistry , aniline , acetylene , quinoline , intramolecular force , catalysis , yield (engineering) , acetonitrile , one pot synthesis , medicinal chemistry , proton nmr , elemental analysis , column chromatography , carbon 13 nmr , organic chemistry , polymer chemistry , materials science , metallurgy

The one‐pot synthesis of a novel class of substituted quinoline derivatives with good yields is achieved via the Cu‐catalyzed intramolecular C─H activation reaction between isocyanides, aniline, and acetylene dicarboxylate in MeCN at room temperature. The existence of one‐pot conditions, availability of a starting material‐catalyst, the absence of column chromatography, and a high yield of products are among the advantages of this method. The structures are confirmed spectroscopically ( 1 H NMR and 13 C NMR, IR, and EI‐MS) and through elemental analyses.

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