Premium
Design, Synthesis, and Evaluation of Tetraethylene Glycol‐Tethered Isatin–1,2,3‐Triazole–Coumarin Hybrids as Novel Anticancer Agents
Author(s) -
Xu Zhi,
Zhao ShiJia,
Lv ZaoSheng,
Gao Feng,
Wang YinLing,
Zhang Feng,
Bai LiuYang,
Deng JiaLun,
Wang Qin,
Fan YiLei
Publication year - 2019
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.3475
Subject(s) - coumarin , chemistry , isatin , combinatorial chemistry , in vitro , hybrid , triazole , stereochemistry , cell culture , cancer cell lines , organic chemistry , biochemistry , cancer , cancer cell , botany , genetics , biology , medicine
We report herein the design and synthesis of a series of novel tetraethylene glycol‐tethered isatin–1,2,3‐triazole–coumarin hybrids and evaluate their in vitro antitumor activities against seven common human cancer cell lines including drug‐resistant cell line. Results revealed that all the synthesized hybrids showed weak to moderate activities against the tested seven cancer cell lines. The structure–activity relationship was also discussed, and the enriched structure–activity relationship may pave the way for further rationale design of this kind of hybrids.