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A Facile Synthesis of Substituted 2‐(5‐(Benzylthio)‐1,3,4‐oxadiazol‐2‐yl)pyrazine Using Microwave Irradiation and Conventional Method with Antioxidant and Anticancer Activities
Author(s) -
Patil Sanjeev R.,
Sarkate Aniket P.,
Karnik Kshipra S.,
Arsondkar Ashish,
Patil Vrushali,
Sangshetti Jaiprakash N.,
Bobade Anil S.,
Shinde Devanand B.
Publication year - 2019
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.3464
Subject(s) - pyrazine , chemistry , microwave irradiation , antioxidant , microwave , combinatorial chemistry , organic chemistry , nuclear chemistry , catalysis , physics , quantum mechanics
A series of novel substituted 2‐(5‐(benzylthio)‐1,3,4‐oxadiazol‐2‐yl)pyrazine derivatives ( 6a – n ) were synthesized under microwave irradiation and conventional conditions with less reaction time with good to excellent yields. All the synthesized compounds were screened for antioxidant and anticancer activities. Out of the 14 prepared derivatives, compounds 6f and 6m were most potent and active with antioxidant and anticancer activities, respectively. Also, the developed technique was simple, easy, and less time consuming.