Premium
Synthesis of Imidazo[1,2‐ a ]pyridines and Imidazo[2,1‐ b ]thiazoles Attached to a Cycloalkyl or Saturated Heterocycle Containing a Tertiary Hydroxy Substitution
Author(s) -
Chenna Reddy M. L.,
Patil Vineetkumar B.,
Nawaz Khan Fazlur Rahman,
Saravanan Vadivelu
Publication year - 2019
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.3454
Subject(s) - chemistry , substitution (logic) , aminopyridines , medicinal chemistry , combinatorial chemistry , stereochemistry , computer science , programming language
A new method has been developed for the synthesis of imidazo[1,2‐ a ]pyridines, imidazo[2,1‐ b ]thiazoles, and benzo[ d ]imidazo[2,1‐ b ]thiazoles attached to a cycloalkyl or saturated heterocycle containing a tertiary hydroxy substitution. Readily available substituted 2‐aminopyridines, 2‐aminothiazoles, and 2‐aminobenzothiazoles were treated with bromohydroxycycloalkyl ethanones to afford the desired products in good yields.