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A Novel Iron‐catalyzed One‐pot Synthesis of 3‐Amino‐1,2,4‐triazoles
Author(s) -
Rohand Taoufik,
Mkpenie Victor N.,
El Haddad Mohammadine,
Markó István E.
Publication year - 2019
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.3450
Subject(s) - chemistry , oxidizing agent , catalysis , yield (engineering) , intramolecular force , combinatorial chemistry , medicinal chemistry , organic chemistry , metallurgy , materials science
A novel one‐pot synthesis of 3‐amino‐1,2,4‐triazole developed via iron (III) catalyzed route is reported. The new method is more efficient, simple, and convenient and presents a concise new strategy for the synthesis of 3‐amino‐1,2,4‐triazole derivatives. The iron (III) complex intermediate assisted in the intramolecular bond cyclization owing to its Lewis acidity or oxidizing properties. A series of aromatic nitriles bearing different electron‐donating and electron‐withdrawing groups substituted at para and/or ortho positions were also investigated. The position of the substituents affected the yield of the final compound, with the para‐substituted substrates giving relatively higher yields.