Copper‐Catalyzed Synthesis of 13‐Aminoisoquinolino[2,1‐ a ]perimidine‐12‐carboxylates  via  α‐Arylation with a High Chemoselectivity | Zendy

Huang MengQiao | Zendy; Liu JianQuan | Zendy; Wang XiangShan | Zendy

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Copper‐Catalyzed Synthesis of 13‐Aminoisoquinolino[2,1‐ a ]perimidine‐12‐carboxylates via α‐Arylation with a High Chemoselectivity

Author(s) -

Huang MengQiao,

Liu JianQuan,

Wang XiangShan

Publication year - 2019

Publication title -

journal of heterocyclic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.321

H-Index - 59

eISSN - 1943-5193

pISSN - 0022-152X

DOI - 10.1002/jhet.3445

Subject(s) - chemistry , chemoselectivity , catalysis , nucleophile , medicinal chemistry , proline , carboxylate , ethyl cyanoacetate , organic chemistry , combinatorial chemistry , amino acid , biochemistry , malononitrile

The α‐arylation between cyanoacetate and 2‐(2‐bromophenyl)‐1 H ‐perimidine took place first catalyzed by CuI/L‐proline in the presence of NaHCO 3 , and then the amino on perimidine chemoselectively attacked the cyano group to undergo a nucleophilic addition, giving a series of 13‐aminoisoquinolino[2,1‐ a ]perimidine‐12‐carboxylate derivatives in good yields.

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