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Copper‐Catalyzed Synthesis of 13‐Aminoisoquinolino[2,1‐ a ]perimidine‐12‐carboxylates via α‐Arylation with a High Chemoselectivity
Author(s) -
Huang MengQiao,
Liu JianQuan,
Wang XiangShan
Publication year - 2019
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.3445
Subject(s) - chemistry , chemoselectivity , catalysis , nucleophile , medicinal chemistry , proline , carboxylate , ethyl cyanoacetate , organic chemistry , combinatorial chemistry , amino acid , biochemistry , malononitrile
The α‐arylation between cyanoacetate and 2‐(2‐bromophenyl)‐1 H ‐perimidine took place first catalyzed by CuI/L‐proline in the presence of NaHCO 3 , and then the amino on perimidine chemoselectively attacked the cyano group to undergo a nucleophilic addition, giving a series of 13‐aminoisoquinolino[2,1‐ a ]perimidine‐12‐carboxylate derivatives in good yields.