z-logo
Premium
Synthesis of Some New Pyrazolone‐Based Heterocycles Containing Sulphone Moiety Acting as α‐Glucosidase and α‐Amylase Inhibitors
Author(s) -
Eldebss Taha M. A.,
Farag Ahmad M.,
Abdalla Mohamed M.,
Khedr Ahmad A.
Publication year - 2019
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.3433
Subject(s) - chemistry , pyrazolone , moiety , amylase , docking (animal) , enzyme , pyrazolones , stereochemistry , combinatorial chemistry , medicinal chemistry , organic chemistry , medicine , nursing
A new series derived from 4‐(2‐chloroacetyl)‐1,2‐dihydro‐2,3‐dimethyl‐1‐phenylpyrazol‐5‐one was synthesized and characterized, and its pharmacological activity toward α‐glucosidase and α‐amylase enzyme inhibition was screened. Moreover, molecular docking studies were conducted to support the findings.

This content is not available in your region!

Continue researching here.

Having issues? You can contact us here