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Synthesis of Some New Pyrazolone‐Based Heterocycles Containing Sulphone Moiety Acting as α‐Glucosidase and α‐Amylase Inhibitors
Author(s) -
Eldebss Taha M. A.,
Farag Ahmad M.,
Abdalla Mohamed M.,
Khedr Ahmad A.
Publication year - 2019
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.3433
Subject(s) - chemistry , pyrazolone , moiety , amylase , docking (animal) , enzyme , pyrazolones , stereochemistry , combinatorial chemistry , medicinal chemistry , organic chemistry , medicine , nursing
A new series derived from 4‐(2‐chloroacetyl)‐1,2‐dihydro‐2,3‐dimethyl‐1‐phenylpyrazol‐5‐one was synthesized and characterized, and its pharmacological activity toward α‐glucosidase and α‐amylase enzyme inhibition was screened. Moreover, molecular docking studies were conducted to support the findings.