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An efficient one‐pot synthesis of N ‐(1,3‐diphenyl‐1 H ‐pyrazol‐ 5‐yl)amides
Author(s) -
Su WeiNien,
Lin TsungPing,
Cheng KaungMin,
Sung KuanChin,
Lin ShaoKai,
Wong Fung Fuh
Publication year - 2010
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.343
Subject(s) - chemistry , phenylhydrazine , acylation , organic chemistry , combinatorial chemistry , medicinal chemistry , catalysis
A “one‐pot” method for the synthesis of N ‐(1,3‐diphenyl‐1 H ‐pyrazol‐5‐yl)amides was developed by cyclization of benzoylacetonitrile ( 1 ) and phenylhydrazine in neat condition followed by acylation . The corresponding N ‐(1,3‐diphenyl‐1 H ‐pyrazol‐5‐yl)amides were provided in good to excellent yields (70–90%). The significant advantages of the new synthetic method are excellent yields and simple work‐up procedure without isolation and purification of intermediary 5‐amino‐1,3‐diphenyl pyrazol ( 2 ). J. Heterocyclic Chem., (2010).