An efficient one‐pot synthesis of N ‐(1,3‐diphenyl‐1 H ‐pyrazol‐ 5‐yl)amides

A “one‐pot” method for the synthesis of N ‐(1,3‐diphenyl‐1 H ‐pyrazol‐5‐yl)amides was developed by cyclization of benzoylacetonitrile ( 1 ) and phenylhydrazine in neat condition followed by acylation . The corresponding N ‐(1,3‐diphenyl‐1 H ‐pyrazol‐5‐yl)amides were provided in good to excellent yields (70–90%). The significant advantages of the new synthetic method are excellent yields and simple work‐up procedure without isolation and purification of intermediary 5‐amino‐1,3‐diphenyl pyrazol ( 2 ). J. Heterocyclic Chem., (2010).