Premium
Design, Synthesis, and Biological Evaluation of 2‐(4‐Aminophenyl)benzothiazole Analogues as Antiproliferative Agents
Author(s) -
Narva Suresh,
Chitti Surendar,
Amaroju Suresh,
Goud Sridhar,
Alvala Mallika,
Bhattacharjee Debanjan,
Jain Nishant,
Kondapalli Venkata Gowri Chandra Sekhar
Publication year - 2019
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.3427
Subject(s) - chemistry , hela , benzothiazole , sulforhodamine b , cancer cell lines , docking (animal) , stereochemistry , cancer cell , cell culture , proton nmr , combinatorial chemistry , cancer , in vitro , cytotoxicity , biochemistry , medicine , nursing , biology , genetics
A series of 28 novel 2‐(4‐aminophenyl)benzothiazole analogues have been synthesized and characterized using various analytical techniques like 1 H NMR, 13 C NMR, electrospray ionization mass spectrometry, and IR and bioevaluated for their antiproliferative activity over a group of three human cancer cell lines, namely, lung cancer (A549), cervical cancer (HeLa), and breast cancer (MDA‐MB‐231), using sulforhodamine B assay method. Few synthesized molecules ( 5a , 5c , 5d , 5f , 7b , and 7j ) displayed effective growth inhibition (GI 50 ) activity against the tested human cancer cell lines at lower micromolar concentration (GI 50 ) values in the range 0.2–1.7 μM. Noticeably, compound 7b exhibited reasonable activity in all three cancer cell lines in the GI 50 range 0.55–1.2 μM. Further, when 7b was screened for tubulin polymerization inhibition, it exhibited more than 55% inhibition at concentration of 5.0 μM. The molecular docking simulations supported the molecular interactions of the derivatives with the targeted receptor. These derivatives may serve as lead structures for development of potential anticancer drug candidates, and 7b might act as a potential microtubule polymerization inhibitor.