Premium
Microwave‐Assisted Synthesis of N ‐Substituted Maleimide Derivatives as Exogenous Antioxidant Agents
Author(s) -
Rammohan Aluru,
Mallikarjuna Reddy Guda,
Raul Garcia Jarem,
Zyryanov Grigory V.,
Sravya Gundala,
Bakthavatchala Reddy Nemallapudi,
Yuvaraja Gutha
Publication year - 2019
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.3421
Subject(s) - maleimide , chemistry , antioxidant , dpph , acetic acid , organic chemistry
A series of N ‐substituted maleimide derivatives have been developed via acetic acid‐mediated microwave reaction pathway, which was identified as the incomparable method for this maleimide compounds. All the synthesized compounds were tested for antioxidant activity by DPPH and H 2 O 2 methods. Compounds 5h and 5m were displayed with higher antioxidant activity in two methods. The structure–activity relationship demonstrated that the compounds having electron releasing substitutions 5h and 5m generally show beneficial activity than electron capture substitution cores. Thus, compounds 5h and 5m may be useful as an exogenous antioxidant.