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Copper Catalyzed Synthesis of Thiomorpholine Derivatives: A New Entry of Multicomponent Reaction Between Terminal Alkynes, Isothiocyanates, and Aziridines
Author(s) -
SamzadehKermani Alireza
Publication year - 2019
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.3418
Subject(s) - chemistry , isothiocyanate , aryl , alkyl , catalysis , copper , acetylide , iodide , organic chemistry , terminal (telecommunication) , solvent , combinatorial chemistry , medicinal chemistry , telecommunications , computer science
Copper acetylide was reacted with isothiocyanate and aziridines to form 1,4‐thiomorpholine derivatives. Reaction outcome depends highly on the reaction conditions and the particular solvent employed. Optimum conditions are developed using copper iodide in hexafluoro‐2‐isopropanol at 60°C. Both the alkyl‐substituted and aryl‐substituted aziridines and terminal alkynes were studied.