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Convenient and Efficient Method for Synthesis of Bis‐Hetaryl Ketones and Evaluation of Their Antimicrobial Activity
Author(s) -
Abdelhamid Abdou O.,
Gomha Sobhi M.,
ElEnany Waleed A. M. A.
Publication year - 2019
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.3415
Subject(s) - chemistry , antifungal , antimicrobial , aryl , combinatorial chemistry , ring (chemistry) , organic chemistry , antibacterial activity , elemental analysis , medicinal chemistry , bacteria , microbiology and biotechnology , alkyl , genetics , biology
Sodium 1‐aryl‐3‐(3‐(ethoxycarbonyl)‐5‐methyl‐1 H ‐pyrazol‐4‐yl)‐3‐oxoprop‐1‐en‐1‐olate was used as precursor for the preparation of some novel derivatives of various fused azolotriazine ring systems via coupling reactions with hetaryldiazonium salts. Hydrazinolysis of the latter products yielded the corresponding pyrazolopyridazine derivatives. The structures of the products were established by their spectral data and elemental analyses. The antibacterial and antifungal activities of some of the new products were also evaluated.