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Design, Synthesis, and Evaluation of Tetraethylene Glycol Tethered Isatin–Coumarin Hybrids as Novel Anticancer Agents
Author(s) -
Xu Zhi,
Zhao ShiJia,
Deng JiaLun,
Wang Qin,
Lv ZaoSheng,
Fan YiLei
Publication year - 2019
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.3411
Subject(s) - chemistry , isatin , hela , coumarin , du145 , combinatorial chemistry , stereochemistry , in vitro , hybrid , biochemistry , cancer cell , organic chemistry , cancer , botany , biology , lncap , genetics
Herein, we report the design and synthesis of a new set of tetraethylene glycol tethered isatin–coumarin hybrids 7a – l as anticancer agents. Results revealed that all the synthesized hybrids showed no or weak activities against their in vitro antitumor activities against drug‐sensitive HepG2, Hela, A549, DU145, SKOV3, and MCF‐7 as well as drug‐resistant MCF‐7/DOX (doxorubicin‐resistant MCF‐7) human cancer cell lines. The structure–activity relationship was also discussed, and the enriched structure–activity relationship may pave the way for further rationale design of this kind of hybrids.