Premium
4‐Chlorothiazole‐5‐carbaldehydes as Potent Precursors for Synthesis of Some New Pendant N ‐heterocyces Endowed with Anti‐Tumor Activity
Author(s) -
El Azab Islam H.,
Gobouri Adil A.,
Altalhi Tariq A.
Publication year - 2019
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.3406
Subject(s) - hela , chemistry , cytotoxic t cell , cytotoxicity , cell culture , in vitro , cancer cell lines , human breast , cancer , stereochemistry , cancer cell , cancer research , biochemistry , biology , genetics
In our approach to synthesize bioactive molecules, a series of novel N ‐heterocycles were synthesized and evaluated for their in vitro antitumor activity against a panel of three human cancer cell lines, namely, human breast cancer cell line (MCF‐7), human cervical cancer cell line (HeLa), and human prostate cancer PC‐3. The majority of the tested compounds exhibited significant cytotoxic activity toward the tested tumor cell lines. Analogues 33 , 34 , 31 , 38 , 21 , 23 , 22 , and 20 exhibited considerable cytotoxic activities comparable with standard drug 5‐fuorouracil. Compound 33 displayed superior cytotoxicity with IC 50 value of 4.12 ± 1.21 μg/mL against HeLa tumor cell line.